Title: Metabotropic Glutamate Receptors Promote Disinhibition of Olfactory Bulb Glomeruli That Scales With
نویسندگان
چکیده
Title: Metabotropic glutamate receptors promote disinhibition of olfactory bulb glomeruli that scales with 1 input strength 2 3 Authors: Joseph D. Zak, Jennifer D. Whitesell, and Nathan E. Schoppa 4 5 Affiliations: 6 1. Neuroscience Program, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045 7 2. Department of Physiology and Biophysics, University of Colorado, Anschutz Medical Campus, 8 Aurora, Colorado 80045 9 10 Running Head: mGluRs promote disinhibition of olfactory bulb glomeruli 11 12
منابع مشابه
Metabotropic glutamate receptors promote disinhibition of olfactory bulb glomeruli that scales with input strength.
Increasing evidence indicates that the neural circuitry within glomeruli of the olfactory bulb plays a major role in affecting information flow between olfactory sensory neurons (OSNs) and output mitral cells (MCs). Glutamatergic external tufted (ET) cells, located at glomeruli, can act as intermediary cells in excitation between OSNs and MCs, whereas activation of MCs by OSNs is, in turn, supp...
متن کاملDetecting activity in olfactory bulb glomeruli with astrocyte recording.
In the olfactory bulb, axons of olfactory sensory neurons (OSNs) expressing the same olfactory receptor converge on specific glomeruli. These afferents form axodendritic synapses with mitral/tufted and periglomerular cell dendrites, whereas the dendrites of mitral/tufted cells and periglomerular interneurons form dendrodendritic synapses. The two types of intraglomerular synapses appear to be s...
متن کاملDisynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb.
Sensory systems often respond to rapid stimuli with high frequency and fidelity, as perhaps best exemplified in the auditory system. Fast synaptic responses are fundamental requirements to achieve this task. The importance of speed is less clear in the olfactory system. Moreover, olfactory bulb output mitral cells respond to a single stimulation of the sensory afferents with unusually long EPSP...
متن کاملLong-term depression at olfactory nerve synapses.
The synapses formed by the olfactory nerve (ON) convey sensory information to olfactory glomeruli, the first stage of central odor processing. Morphological and behavioral studies suggest that glomerular odor processing is plastic in neonate rodents. However, long-term synaptic plasticity, a cellular correlate of functional and structural plasticity, has not yet been demonstrated in this system...
متن کاملPeripheral adaptation codes for high odor concentration in glomeruli.
Adaptation is a general property of sensory receptor neurons and has been extensively studied in isolated cell preparation of olfactory receptor neurons. In contrast, little is known about the conditions under which peripheral adaptation occurs in the CNS during odorant stimulation. Here, we used two-photon laser-scanning microscopy and targeted extracellular recording in freely breathing anest...
متن کامل